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Cagrilintide is a long-acting, lipidated amylin analogue 1 Retatrutide is a single-peptide triple agonist 6 At the receptor level, Cagrilintide acts as a nonselective agonist at amylin receptors and the calcitonin receptor 2 Retatrutide has agonist activity at GIPR, GLP-1R and GCGR 6 Cagrilintide has a distinct binding, activation and regulatory profile across calcitonin-family receptors 2 The mechanistic profile of Retatrutide encompasses GIPR and GLP-1R signalling plus a GCGR arm whose contribution to energy expenditure was studied preclinically Cagrilintide emerged from a structure-activity programme designed to create a stable, lipidated, long-acting amylin analogue 1

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